Detailed view for MUL_2252

Basic information

TDR Targets ID: 954414
Mycobacterium ulcerans, sugar-transport ATP-binding protein ABC transporter
Source Database / ID:  KEGG  

pI: 6.5049 | Length (AA): 356 | MW (Da): 39131 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF08402   TOBE domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0043190   ATP-binding cassette (ABC) transporter complex  
GO:0022857   transmembrane transporter activity  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  
GO:0055085   transmembrane transport  

Metabolic Pathways

ABC transporters (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 355 1g29 (1) 1 371 49.00 0 1 1.50459 -0.49
1 355 2d62 (A) 4 374 50.00 0 1 1.52659 -0.61
3 228 4huq (A) 2 238 30.00 0 1 1.06623 -1.2
4 216 3tif (A) 2 225 35.00 0 1 1.06921 -1.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128894)

Species Accession Gene Product
Escherichia coli b4035   fused maltose transport subunit, ATP-binding component of ABC superfamily/regulatory protein
Escherichia coli b3450   glycerol-3-phosphate transporter subunit
Mycobacterium leprae ML1424c   Probable sugar-transport ATP-binding protein ABC transporter
Mycobacterium leprae ML1089   PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC
Mycobacterium tuberculosis Rv2832c   Probable Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC
Mycobacterium tuberculosis Rv2038c   Probable sugar-transport ATP-binding protein ABC transporter
Mycobacterium tuberculosis Rv1238   Probable sugar-transport ATP-binding protein ABC transporter SugC
Mycobacterium ulcerans MUL_2252   sugar-transport ATP-binding protein ABC transporter
Schistosoma japonicum Sjp_0127860   ko:K02010 iron(III) transport system ATP-binding protein, putative
Schmidtea mediterranea mk4.043429.00  
Treponema pallidum TP0804   sugar ABC transporter ATP-binding protein

Essentiality

MUL_2252 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2070 Mycobacterium tuberculosis non-essential nmpdr
mtu1259 Mycobacterium tuberculosis non-essential nmpdr
mtu2879 Mycobacterium tuberculosis essential nmpdr
b3450 Escherichia coli non-essential goodall
b4035 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier MUL_2252 (Mycobacterium ulcerans), sugar-transport ATP-binding protein ABC transporter
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